HCID 50908295, compound → HCID 50908296, compound

HRID 1644760Notes

Reaction equation

HRID 1644760 reaction equation
C([O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11](=[O:22])[NH:12][C:13]1[S:14][CH:15]=[C:16]([S:18]([CH3:21])(=[O:20])=[O:19])[N:17]=1)(=O)C>Cl>[OH:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]([NH:12][C:13]1[S:14][CH:15]=[C:16]([S:18]([CH3:21])(=[O:20])=[O:19])[N:17]=1)=[O:22]

Participants

3

Reactant 1

HCID 50908295HCID 50908295, compound

Product 1

HCID 50908296HCID 50908296, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

2-{[4-(methylsulfonyl)-1,3-thiazol-2-yl]carbamoyl}phenyl acetate (62, 118.2 mg, 0.3473 mmol) was suspended in conc. hydrochloric acid (2.0 mL) and stirred rapidly. The slurry become homogenous momentarily, and then re-precipitates. The suspension was stirred rapidly at 50° C. for 16 hours before cooling, and filtering on a fine fritted funnel. The solids were washed with water (ca. 5 mL), and dried in vacuo to give 60 as a colorless powder.

Workup

  1. customre-precipitates
  2. stirringThe suspension was stirred rapidly at 50° C. for 16 hours
  3. temperaturebefore cooling
  4. filtrationfiltering on a fine fritted funnel
  5. washThe solids were washed with water (ca. 5 mL)
  6. customdried in vacuo

Sources & evidence

ORD record
ord-ad70d58ed4664fcda0bdaff7edbeec7c
Source dataset
uspto-grants-2012_02
Patent number
US08124632B2

Reaction notes

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