Ammonia → HCID 66773538, compound

HRID 1644798Notes

Reaction equation

HRID 1644798 reaction equation
[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C:9]1([CH2:16][O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13](O)=[O:14])=[O:7])([CH3:4])([CH3:3])[CH3:2].[NH3:25]>O>[C:1]([O:5][C:6]([N:8]1[CH2:12][CH2:11][CH2:10][C:9]1([CH2:16][O:17][CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13](=[O:14])[NH2:25])=[O:7])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 222AmmoniaHCID 66773211HCID 66773211, compound

Product 1

HCID 66773538HCID 66773538, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

This material was prepared in analogy to example 1 and 2, step A, using 2-benzyloxymethyl-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester (1.426 g, see example 12, step A) and ammonia solution (320 μL of a 25% solution in water) to give the desired (rac)-2-benzyloxymethyl-2-carbamoyl-pyrrolidine-1-carboxylic acid tert-butyl ester (1.5 g, MS (ES+): 335.3 (MH+)) as a yellow oil.

Workup

  1. customThis material was prepared in analogy to example 1 and 2, step A

Sources & evidence

ORD record
ord-4572ff55a7e647aa8e6734884472c2ca
Source dataset
uspto-grants-2012_02
Patent number
US08124636B2

Reaction notes

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