Cyclopentanol → HCID 44611781, compound

HRID 1645154Notes

Reaction equation

[CH2:1]([O:3][C:4](=[O:28])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][C@@H:10]([N:15]([S:17]([C:20]3[CH:25]=[CH:24][C:23](F)=[C:22]([Cl:27])[CH:21]=3)(=[O:19])=[O:18])[CH3:16])[C:9]=2[CH:8]=[N:7]1)[CH3:2].[CH:29]1([OH:34])[CH2:33][CH2:32][CH2:31][CH2:30]1>>[CH2:1]([O:3][C:4](=[O:28])[CH2:5][N:6]1[C:14]2[CH2:13][CH2:12][CH2:11][C@@H:10]([N:15]([S:17]([C:20]3[CH:25]=[CH:24][C:23]([O:34][CH:29]4[CH2:33][CH2:32][CH2:31][CH2:30]4)=[C:22]([Cl:27])[CH:21]=3)(=[O:19])=[O:18])[CH3:16])[C:9]=2[CH:8]=[N:7]1)[CH3:2]

Participants

Reactant 2

HCID 7298Cyclopentanol

HCID 44611780HCID 44611780, compound

Product 1

HCID 44611781HCID 44611781, compound

Procedure

Starting with {(R)-4-[(3-chloro-4-fluoro-benzenesulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester and cyclopentanol using the method analogous to the one described above for example 3-1, {(R)-4-[(3-chloro-4-cyclopentyloxy-benzenesulfonyl)-methyl-amino]-4,5,6,7-tetrahydro-indazol-1-yl}-acetic acid ethyl ester was obtained. MS cald. for C23H30ClN3O5S 495, obsd. (ESI+) [(M+H)+] 496.

Sources & evidence

ORD record: ord-f34fe23a73cf4eac9919a23035620e2d
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08124641B2

Reaction notes

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