Dimethylformamide dimethyl acetal → HCID 66774604, compound

HRID 1645223Notes

Reaction equation

HRID 1645223 reaction equation
[C:1]([C:4]1[C:9]([Br:10])=[CH:8][C:7]([C:11]([F:14])([F:13])[F:12])=[CH:6][N:5]=1)(=[O:3])[CH3:2].CO[CH:17](OC)[N:18]([CH3:20])[CH3:19]>C1(C)C=CC=CC=1>[Br:10][C:9]1[C:4]([C:1](=[O:3])[CH:2]=[CH:17][N:18]([CH3:20])[CH3:19])=[N:5][CH:6]=[C:7]([C:11]([F:13])([F:14])[F:12])[CH:8]=1

Participants

4

Reactant 2

HCID 78373Dimethylformamide dimethyl acetalHCID 667748471-[3-Bromo-5-(trifluoromethyl)pyridin-2-yl]ethan-1-one

Product 1

HCID 66774604HCID 66774604, compoundYield 98.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

728 mg of 2-acetyl-3-bromo-5-(trifluoromethyl)pyridine and 466 mg of N,N-dimethylformamide dimethyl acetal were reacted in 5 mL of toluene at 100° C. for 16 hours. The reaction liquid was concentrated under reduced pressure to obtain 866 mg of 1-(3-bromo-5-(trifluoromethyl)pyridin-2-yl)-3-(dimethylamino)-2-propen-1-one (after-mentioned intermediate No. IV-7).

Workup

  1. customThe reaction liquid
  2. concentrationwas concentrated under reduced pressure

Sources & evidence

ORD record
ord-97136fe34dd74869bedd208530bbcc63
Source dataset
uspto-grants-2012_02
Patent number
US08124760B2

Reaction notes

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