Piperidine → HCID 66773118, compound

HRID 1645278Notes

Reaction equation

[CH:1]([C:3]1[O:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([NH2:17])(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)=O.[Cl:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[CH2:22]2.N1CCCCC1>CCO>[Cl:18][C:19]1[CH:20]=[C:21]2[C:25](=[CH:26][CH:27]=1)[NH:24][C:23](=[O:28])[C:22]2=[CH:1][C:3]1[O:7][C:6]([C:8]2[CH:9]=[CH:10][C:11]([S:14]([NH2:17])(=[O:15])=[O:16])=[CH:12][CH:13]=2)=[CH:5][CH:4]=1

Participants

Conditions

Temperature: 70 °C

Procedure

To 4-(5-formylfuran-2-yl)benzenesulfonamide (30 mg, 0.120 mmol) in EtOH was added 5-chlorooxindole (20 mg, 0.120 mmol) and piperidine (12 μL, 0.120 mmol). The mixture was stirred at 70° C. for several hours. The solid formed was isolated by filtration and air dried to yield 4-(5-((5-chloro-2-oxoindolin-3-ylidene)methyl)furan-2-yl)benzenesulfonamide. LC-MS (M+1=401).

Workup

customThe solid formed
customwas isolated by filtration and air
customdried

Sources & evidence

ORD record: ord-49e79869028a42978ae326a540dead33
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08124649B2

Reaction notes

Loading…