Tetrahydrofuran → 6-(Benzenesulfonyl)-8-benzyl-2-[2-[2-cyclopropyloxy-5-(trifluoromethoxy)phenyl]ethynyl]-1-phenyl-8-azabicyclo[3.2.1]octan-2-ol
Reaction equation
[CH2:1]([Li:2])[CH2:3][CH2:4][CH3:5].[CH2:27]([c:28]1[cH:29][cH:30][cH:31][cH:32][cH:33]1)[N:34]1[C:35]2([c:52]3[cH:53][cH:54][cH:55][cH:56][cH:57]3)[C:36](=[O:51])[CH2:37][CH2:38][CH:39]1[CH:40]([S:42](=[O:43])(=[O:44])[c:45]1[cH:46][cH:47][cH:48][cH:49][cH:50]1)[CH2:41]2.[CH:6]1([O:9][c:10]2[c:11]([C:21]#[CH:22])[cH:12][c:13]([O:16][C:17]([F:18])([F:19])[F:20])[cH:14][cH:15]2)[CH2:7][CH2:8]1.[Cl:23][Ce:24]([Cl:25])[Cl:26].[O:58]1[CH2:59][CH2:60][CH2:61][CH2:62]1>>[CH:6]1([O:9][c:10]2[c:11]([C:21]#[C:22][C:36]3([OH:51])[C:35]4([c:52]5[cH:53][cH:54][cH:55][cH:56][cH:57]5)[N:34]([CH2:27][c:28]5[cH:29][cH:30][cH:31][cH:32][cH:33]5)[CH:39]([CH2:38][CH2:37]3)[CH:40]([S:42](=[O:43])(=[O:44])[c:45]3[cH:46][cH:47][cH:48][cH:49][cH:50]3)[CH2:41]4)[cH:12][c:13]([O:16][C:17]([F:18])([F:19])[F:20])[cH:14][cH:15]2)[CH2:7][CH2:8]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-db6da6554b634ed38445df7cdd41104f
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (9/10)
Reaction notes
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