6,7-Diethoxy-3-methyl-1-benzofuran-2-carboxylic acid → 3-{4-[(6,7-Diethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid ethyl ester

HRID 1645370Notes

Reaction equation

HRID 1645370 reaction equation
[CH2:1]([O:3][C:4]1[CH:16]=[CH:15][C:7]2[C:8]([CH3:14])=[C:9]([C:11]([OH:13])=O)[O:10][C:6]=2[C:5]=1[O:17][CH2:18][CH3:19])[CH3:2].[CH2:20]([O:22][C:23]([N:25]1[CH2:29][CH2:28][CH:27]([O:30][C:31]2[CH:36]=[CH:35][C:34]([NH2:37])=[CH:33][CH:32]=2)[CH2:26]1)=[O:24])[CH3:21]>>[CH2:20]([O:22][C:23]([N:25]1[CH2:29][CH2:28][CH:27]([O:30][C:31]2[CH:32]=[CH:33][C:34]([NH:37][C:11]([C:9]3[O:10][C:6]4[C:5]([O:17][CH2:18][CH3:19])=[C:4]([O:3][CH2:1][CH3:2])[CH:16]=[CH:15][C:7]=4[C:8]=3[CH3:14])=[O:13])=[CH:35][CH:36]=2)[CH2:26]1)=[O:24])[CH3:21]

Participants

3

Reactant 2

HCID 7447606,7-Diethoxy-3-methyl-1-benzofuran-2-carboxylic acidHCID 667727903-(4-Amino-phenoxy)-pyrrolidine-1-carboxylic acid ethyl ester

Product 1

HCID 593651863-{4-[(6,7-Diethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid ethyl ester

Procedure

With a procedure similar to example above, 3-{4-[(6,7-diethoxy-3-methyl-benzofuran-2-carbonyl)-amino]-phenoxy}-pyrrolidine-1-carboxylic acid ethyl ester was prepared from 6,7-diethoxy-3-methyl-benzofuran-2-carboxylic acid and 3-(4-amino-phenoxy)-pyrrolidine-1-carboxylic acid ethyl ester. LCMS calcd for C27H32N2O7 (m/e) 496, obsd 497 (M+H).

Sources & evidence

ORD record
ord-eed3f273e34c42f78c184d9e428e6ad4
Source dataset
uspto-grants-2012_02
Patent number
US08124766B2

Reaction notes

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