참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Benzyl Chloride | HCID 7503 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | Desbenzyl donepezil | HCID 10446897 | — |
| 촉매 | Tetrabutylammonium Iodide | HCID 67553 | — |
| 용매 | Acetone | HCID 180 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Donepezil | HCID 3152 | — |
반응 단계
4-[(5,6-Dimethoxy-1-indanon-2-yl)methyl]piperidine (4 g) was taken in acetone (60 ml). To which benzyl chloride (1.92 g), potassium carbonate (2.28 g) and a catalytic quantity of tetrabutylammonium iodide (TBAI) were added. The reaction mixture was heated at 60° C. and reaction was monitored on TLC. Solvent was removed by distillation after reaction completion and the residue was taken in water and extracted with ethyl acetate (100 ml). The organic extract was acidified with cone. HCl. The solvent was evaporated under vacuum to yield the salt as a residue. Yield: 5.14 g.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08124783B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_02 |
|---|
| ORD ID | ord-7fca73cdba884ff9b8ca8b216c86ef8c |
|---|
| 출처 메모 | uspto-grants-2012_02 |
|---|
