Ethyl Acetoacetate → 2-(2,5,5-Trimethyl-1,3-dioxan-2-yl)ethanol

HRID 1645589Notes

Reaction equation

[CH2:1]([C:4]1(CCO)OCCC[O:5]1)[CH2:2][CH3:3].C(OCC)(=O)CC(C)=O.[CH3:22][C:23]([CH3:28])([CH2:26][OH:27])[CH2:24][OH:25]>>[CH3:3][C:2]1([CH2:1][CH2:4][OH:5])[O:27][CH2:26][C:23]([CH3:28])([CH3:22])[CH2:24][O:25]1

Participants

Reactant 3

HCID 8868Ethyl Acetoacetate

HCID 31344Neopentyl glycol

HCID 597924352-(2-Propyl-1,3-dioxan-2-yl)ethanol

Product 1

HCID 232529502-(2,5,5-Trimethyl-1,3-dioxan-2-yl)ethanolYield 55%

Procedure

The same procedure as in the steps (8a) and (8b) of Example 8 was repeated using ethyl acetoacetate, and 2,2-dimethyl-1,3-propanediol to obtain the title compound (7.3 g, total yield: 55%) as a light yellow oil.

Sources & evidence

ORD record: ord-31fa172e6b4c45cfbbae7b4573c05ab9
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08124780B2

Reaction notes

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