(1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol → 2-(((4-((1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 1645595Notes

Reaction equation

HRID 1645595 reaction equation
[Na:1].[CH3:2][C:3]1[C:4]([CH2:20][S:21]([C:23]2[NH:27][C:26]3[CH:28]=[CH:29][CH:30]=[CH:31][C:25]=3[N:24]=2)=[O:22])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:10][C:11]12[CH2:18][O:17][C:14]([CH3:19])([O:15][CH2:16]1)[O:13][CH2:12]2.[CH:32]1(C23OCC(CO)(CO2)CO3)C[CH2:33]1>>[Na:1].[CH:19]1([C:14]23[O:15][CH2:16][C:11]([CH2:10][O:9][C:8]4[CH:7]=[CH:6][N:5]=[C:4]([CH2:20][S:21]([C:23]5[NH:24][C:25]6[CH:31]=[CH:30][CH:29]=[CH:28][C:26]=6[N:27]=5)=[O:22])[C:3]=4[CH3:2])([CH2:12][O:13]2)[CH2:18][O:17]3)[CH2:33][CH2:32]1

Participants

3

Reactant 2

HCID 59792605(1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanolHCID 667761922-(((3-Methyl-4-((1-methyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667764152-(((4-((1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 3.2%

Procedure

The same procedure as in the steps (24b) to (24f) of Example 24 was repeated using (1-cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol obtained in the step (37c) above to obtain the title compound (147 mg, total yield: 3.2%) as a light yellow solid.

Workup

  1. customobtained in the step (37c) above

Sources & evidence

ORD record
ord-a983627fce4f42739b99131179d62ee3
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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