HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol → 2-(((4-((1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol | HCID 59792605 | — |
| Reactant | 2-(((3-Methyl-4-((1-methyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776192 | — |
| Product | 2-(((4-((1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776415 | 3.2% |
Reaction Steps
The same procedure as in the steps (24b) to (24f) of Example 24 was repeated using (1-cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol obtained in the step (37c) above to obtain the title compound (147 mg, total yield: 3.2%) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-a983627fce4f42739b99131179d62ee3 |
| Source note | uspto-grants-2012_02 |