Cyanocyclobutane → (1-Cyclobutyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol

HRID 1645596Notes

Reaction equation

HRID 1645596 reaction equation
[CH:1]1([C:4]23[O:11][CH2:10][C:7]([CH2:12][OH:13])([CH2:8][O:9]2)[CH2:6][O:5]3)[CH2:3][CH2:2]1.[CH:14]1(C#N)CCC1>>[CH:1]1([C:4]23[O:5][CH2:6][C:7]([CH2:12][OH:13])([CH2:8][O:9]2)[CH2:10][O:11]3)[CH2:3][CH2:2][CH2:14]1

Participants

3

Reactant 2

HCID 78148CyanocyclobutaneHCID 59792605(1-Cyclopropyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanol

Product 1

HCID 59792382(1-Cyclobutyl-2,6,7-trioxabicyclo[2.2.2]oct-4-yl)methanolYield 51%

Procedure

The same procedure as in the steps (37a) to (37c) of Example 37 was repeated using cyclobutanecarbonitrile to obtain the title compound (15 g, total yield: 51%) as a light yellow oil.

Sources & evidence

ORD record
ord-0a6c2d11c0714f15af0abe829eaa77a1
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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