Methyl 4-methoxyacetoacetate → 2-(2-(Methoxymethyl)-1,3-dioxolan-2-yl)ethanol

HRID 1645607Notes

Reaction equation

HRID 1645607 reaction equation
[CH2:1]([C:3]1([CH2:8][CH2:9][OH:10])[O:7][CH2:6][CH2:5][O:4]1)C.[CH3:11][O:12]CC(=O)CC(OC)=O>>[CH3:11][O:12][CH2:1][C:3]1([CH2:8][CH2:9][OH:10])[O:4][CH2:5][CH2:6][O:7]1

Participants

3

Reactant 2

HCID 123500Methyl 4-methoxyacetoacetateHCID 139403682-(2-Ethyl-1,3-dioxolan-2-yl)ethan-1-ol

Product 1

HCID 597925682-(2-(Methoxymethyl)-1,3-dioxolan-2-yl)ethanolYield 50%

Procedure

The same procedure as in the step (39a) and (39b) of Example 39 was repeated using methyl 4-methoxyacetoacetate to obtain the title compound (5.3 g, 2 steps: 50%) as a colorless oil.

Sources & evidence

ORD record
ord-5e0c73bb359d4ff3a6380d2798e51d99
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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