m-Chloroperbenzoic acid → 2-(((4-(1,3-Dioxolan-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Participants

Role	Name	HCID	Charge
Reactant	m-Chloroperbenzoic acid	HCID 70297	—
Reactant	1,3-Dioxolane-2-methanol	HCID 294864	—
Reactant	2-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt	HCID 66776196	—
Product	2-(((4-(1,3-Dioxolan-2-ylmethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt	HCID 66776143	17.2%

Reaction Steps

The same procedure as in the steps (4f) to (4j) described in Example (a reprecipitation operation was not performed in oxidation step with 3-chloroperbenzoic acid) was repeated using 1,3-dioxolan-2-ylmethanol obtained in the step (66b) above to obtain the title compound (411 mg, total 17.2% yield) as a white solid.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08124780B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-66bff0e5a73b48e59f5042260bbef4ab
Source note	uspto-grants-2012_02