2-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol → 2-(((3-Methyl-4-(2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 1645641Notes

Reaction equation

HRID 1645641 reaction equation
[Na:1].[CH2:2]([C:4]1([CH2:14][CH2:15][O:16][C:17]2[CH:22]=[CH:21][N:20]=[C:19]([CH2:23][S:24]([C:26]3[NH:30][C:29]4[CH:31]=[CH:32][CH:33]=[CH:34][C:28]=4[N:27]=3)=[O:25])[C:18]=2[CH3:35])[O:13][CH2:12][C:7]2([O:11][CH2:10][CH2:9][O:8]2)[CH2:6][O:5]1)C.CC1(CCO)OCC2(OCCO2)CO1>>[Na:1].[CH3:35][C:18]1[C:19]([CH2:23][S:24]([C:26]2[NH:27][C:28]3[CH:34]=[CH:33][CH:32]=[CH:31][C:29]=3[N:30]=2)=[O:25])=[N:20][CH:21]=[CH:22][C:17]=1[O:16][CH2:15][CH2:14][C:4]1([CH3:2])[O:13][CH2:12][C:7]2([O:8][CH2:9][CH2:10][O:11]2)[CH2:6][O:5]1

Participants

3

Reactant 2

HCID 597925642-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanolHCID 667761962-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667758662-(((3-Methyl-4-(2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium saltYield 15.1%

Procedure

The same procedure as in the steps (4f) to (4j) of Example 4 was repeated using 2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol obtained in the step (73b) above to obtain the title compound (298 mg, total 15.1% yield) as a white solid.

Workup

  1. customobtained in the step (73b) above

Sources & evidence

ORD record
ord-d53ab82b73314007b3430b5927348788
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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