HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol → 2-(((3-Methyl-4-(2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(8-Methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol | HCID 59792564 | — |
| Reactant | 2-(((4-(2-(8-Ethyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66776196 | — |
| Product | 2-(((3-Methyl-4-(2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethoxy)pyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt | HCID 66775866 | 15.1% |
Reaction Steps
The same procedure as in the steps (4f) to (4j) of Example 4 was repeated using 2-(8-methyl-1,4,7,9-tetraoxaspiro[4.5]dec-8-yl)ethanol obtained in the step (73b) above to obtain the title compound (298 mg, total 15.1% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08124780B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-d53ab82b73314007b3430b5927348788 |
| Source note | uspto-grants-2012_02 |