5,5-Dimethyl-1,3-dioxane-2-ethanol → 2-(((4-(2-(5,5-Dimethyl-1,3-dioxan-2-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

HRID 1645657Notes

Reaction equation

HRID 1645657 reaction equation
[Na:1].CC1(C)COC(C[O:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH2:17][S:18]([C:20]3[NH:24][C:23]4[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=4[N:21]=3)=[O:19])[C:12]=2[CH3:29])OC1.[CH3:31][C:32]1([CH3:41])[CH2:37][O:36][CH:35]([CH2:38][CH2:39]O)[O:34][CH2:33]1>>[Na:1].[CH3:31][C:32]1([CH3:41])[CH2:37][O:36][CH:35]([CH2:38][CH2:39][O:10][C:11]2[CH:16]=[CH:15][N:14]=[C:13]([CH2:17][S:18]([C:20]3[NH:24][C:23]4[CH:25]=[CH:26][CH:27]=[CH:28][C:22]=4[N:21]=3)=[O:19])[C:12]=2[CH3:29])[O:34][CH2:33]1

Participants

3

Reactant 2

HCID 41921795,5-Dimethyl-1,3-dioxane-2-ethanolHCID 667765882-(((4-((5,5-Dimethyl-1,3-dioxan-2-yl)methoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Product 1

HCID 667762172-(((4-(2-(5,5-Dimethyl-1,3-dioxan-2-yl)ethoxy)-3-methylpyridin-2-yl)methyl)sulfinyl)-1h-benzimidazole sodium salt

Procedure

The same procedure as in the steps (1c) to (1g) of Example 1 was repeated using 5,5-dimethyl-1,3-dioxane-2-ethanol (1.00 g, 6.24 mmol) to obtain the title compound (138 mg, 0.31 mmol) as a beige solid.

Sources & evidence

ORD record
ord-7791fc01ff2f48a486fcef2eeae50c9c
Source dataset
uspto-grants-2012_02
Patent number
US08124780B2

Reaction notes

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