Hydrochloric Acid → HCID 19390867, compound

HRID 1645859Notes

Reaction equation

HRID 1645859 reaction equation
C([N:4]1[CH2:9][CH2:8][CH:7]([C:10](=[O:23])[C:11]2[CH:16]=[CH:15][C:14]([N:17]3[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]3)=[CH:13][CH:12]=2)[CH2:6][CH2:5]1)(=O)C.[ClH:24]>>[ClH:24].[ClH:24].[N:17]1([C:14]2[CH:13]=[CH:12][C:11]([C:10]([CH:7]3[CH2:8][CH2:9][NH:4][CH2:5][CH2:6]3)=[O:23])=[CH:16][CH:15]=2)[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 152900181-Acetyl-4-(4-piperidinobenzoyl)piperidine

Product 1

HCID 19390867HCID 19390867, compound

Conditions

Temperature
100 °C

Procedure

The 1-acetyl-4-(4-piperidinobenzoyl)piperidine (0.63 g) prepared in Example 1 was dissolved in 10 ml of concentrated hydrochloric acid and the solution was stirred at 100° C. for 3 hours. The solvent was then distilled off under reduced pressure and the residue was recrystallized from ethanol to give 0.5 g of colorless crystals melting at 256°-264° C.

Workup

  1. distillationThe solvent was then distilled off under reduced pressure
  2. customthe residue was recrystallized from ethanol

Sources & evidence

ORD record
ord-c93324771c1c45e598e59149bf94d7d9
Source dataset
uspto-grants-1993_01
Patent number
US05177087

Reaction notes

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