Pyrrolidine → HCID 11724052, compound

HRID 1645873Notes

Reaction equation

[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16](F)=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2].[NH:21]1[CH2:25][CH2:24][CH2:23][CH2:22]1>>[C:1]([N:4]1[CH2:9][CH2:8][CH:7]([CH2:10][CH2:11][C:12](=[O:20])[C:13]2[CH:18]=[CH:17][C:16]([N:21]3[CH2:25][CH2:24][CH2:23][CH2:22]3)=[CH:15][CH:14]=2)[CH2:6][CH2:5]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 31268Pyrrolidine

HCID 9970726HCID 9970726, compound

Product 1

HCID 11724052HCID 11724052, compound

Procedure

Using 3.2 g of 1-acetyl-4-[2-(4 -fluorobenzoyl)ethyl]piperidine and 6 ml of pyrrolidine, the procedure of Example 53 was repeated to give 2.7 g of a colorless oil.

Sources & evidence

ORD record: ord-6c2611a894e742b7864ca4b7c4075924
Source dataset: uspto-grants-1993_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05177087

Reaction notes

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