Pyrrolidine → HCID 10000486, compound

HRID 1645876Notes

Reaction equation

HRID 1645876 reaction equation
[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17](=[O:25])[C:18]2[CH:23]=[CH:22][C:21](F)=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>O1CCOCC1>[CH2:1]([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][CH2:15][CH2:16][C:17](=[O:25])[C:18]2[CH:23]=[CH:22][C:21]([N:26]3[CH2:30][CH2:29][CH2:28][CH2:27]3)=[CH:20][CH:19]=2)[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 10315149HCID 10315149, compound

Product 1

HCID 10000486HCID 10000486, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Conditions

Temperature
100 °C

Procedure

To a solution of the 1-benzyl-4-[3-(4-fluorobenzoyl)propyl]piperidine (0.6 g) synthesized in 4) in dioxane (1 ml) was added 3 ml of pyrrolidine and the mixture was heated at 100° C. for 16 hours. Thereafter, the procedure of Example 37 was repeated to give 0.58 g of 1-benzyl-4-[3-(4-pyrrolidinobenzoyl]propyl]piperidine as colorless crystals melting at 115°-116° C.

Sources & evidence

ORD record
ord-d3c8478021ef4163b3b943f6b60ad178
Source dataset
uspto-grants-1993_01
Patent number
US05177087

Reaction notes

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