反应详情

A mixture of 0.6 g (2.5 mmol) of 5-(3-chloropropoxy)-3,4-dihydro-1(2H)-isoquinolinone and 0.6 ml (10 mmol) of piperidine in 30 ml of ethanol was refluxed for 40 hours. The mixture was concentrated, dissolved in chloroform and washed with saturated sodium bicarbonate. The organic layer was dried and concentrated. The solid was recrystallized from water to provide 0.44 g (61%) of the desired product; mp 112°-114°.

1. temperaturewas refluxed for 40 hours
2. concentrationThe mixture was concentrated
3. dissolutiondissolved in chloroform
4. washwashed with saturated sodium bicarbonate
5. customThe organic layer was dried
6. concentrationconcentrated
7. customThe solid was recrystallized from water