4-Methyloxybenzyl chloride → HCID 19802749, compound

HRID 1645948Notes

Reaction equation

HRID 1645948 reaction equation
[CH2:1]([C:5]1[N:6]([CH2:11][C:12]2[CH:17]=[CH:16][C:15]([OH:18])=[CH:14][CH:13]=2)[C:7](=[S:10])[NH:8][N:9]=1)[CH2:2][CH2:3][CH3:4].[CH3:19][O:20][C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Cl)=[CH:23][CH:22]=1>>[CH2:1]([C:5]1[N:6]([CH2:11][C:12]2[CH:13]=[CH:14][C:15]([OH:18])=[CH:16][CH:17]=2)[C:7]([S:10][CH2:25][C:24]2[CH:27]=[CH:28][C:21]([O:20][CH3:19])=[CH:22][CH:23]=2)=[N:8][N:9]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 699934-Methyloxybenzyl chlorideHCID 19802743HCID 19802743, compound

Product 1

HCID 19802749HCID 19802749, compoundYield 70%

Procedure

Reaction of 5-butyl-2,4-dihydro-4-(4-hydroxybenzyl)-3H-1,2,4-triazole-3-thione (from Example 1, Step D) with 4-methoxybenzyl chloride according to the procedure of Example 5, Step A, gave a 70% yield of the title compound as a solid, mp 130°-131° C.; homogeneous by TLC in 95:5 CH2Cl2 -MeOH.

Sources & evidence

ORD record
ord-a96dcebd984349e6bf9134ec45109280
Source dataset
uspto-grants-1993_01
Patent number
US05177095

Reaction notes

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