N-benzyl-L-alanine → HCID 19100956, compound

HRID 1645986Notes

Reaction equation

HRID 1645986 reaction equation
[CH2:1]([N:4]([CH2:10][CH:11]=O)[C:5](=[O:9])[O:6][CH2:7][CH3:8])[CH:2]=[CH2:3].[CH2:13]([NH:20][C@H:21](C(O)=O)[CH3:22])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>C1(C)C=CC=CC=1>[CH2:13]([N:20]1[CH:21]([CH3:22])[CH2:3][CH:2]2[CH:11]1[CH2:10][N:4]([C:5]([O:6][CH2:7][CH3:8])=[O:9])[CH2:1]2)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

4

Reactant 2

HCID 723764N-benzyl-L-alanineHCID 11084330Ethyl allyl(2-oxoethyl)carbamate

Product 1

HCID 19100956HCID 19100956, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

42.8 g (0.25 mol) of ethyl N-allyl-N-(2-oxoethyl)-carbamate are heated under reflux overnight with 44.8 g (0.25 mol) of N-benzylalanine in 750 ml of toluene. The mixture is concentrated and the residue is distilled twice.

Workup

  1. concentrationThe mixture is concentrated
  2. distillationthe residue is distilled twice

Sources & evidence

ORD record
ord-0c7ffcf2948a4152814a08a8c4258807
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

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