1-Benzyl-5-methyloctahydropyrrolo[3,4-b]pyrrole → 5-Methyl-octahydropyrrolo(3,4-b)pyrrole

HRID 1646013Notes

Reaction equation

HRID 1646013 reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([CH3:16])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][N:11]1[CH2:10][CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12]1

Participants

4

Reactant 1

HCID 191009621-Benzyl-5-methyloctahydropyrrolo[3,4-b]pyrrole

Product 1

HCID 162288995-Methyl-octahydropyrrolo(3,4-b)pyrrole

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

10.3 g (47.6 mmol) of 2-benzyl-7-methyl-2,7-diazabicyclo[3.3.0] octane in 200 ml of ethanol are hydrogenated at 100° C. and 100 bar on 2.5 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. customare hydrogenated at 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-d4cbd5db66da4cb5a56df5be2be77f3a
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

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