HCID 19100964, compound → HCID 16228902, compound

HRID 1646038Notes

Reaction equation

HRID 1646038 reaction equation
C([N:8]1[CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH:9]12[CH2:10][N:11]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:12][CH:13]1[CH2:14][CH:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])[NH:8]2

Participants

4

Reactant 1

HCID 19100964HCID 19100964, compound

Product 1

HCID 16228902HCID 16228902, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

96.5 g (0.279 mol) of diethyl 2-benzyl-2,7-diazabicyclo[3.3.0]octane-3,7-dicarboxylate in 1 l of ethanol are hydrogenated at 100° C. and 100 bar on 5 g of palladium-active carbon (10% Pd). The catalyst is filtered off with suction, the filtrate is concentrated and the residue is distilled.

Workup

  1. customare hydrogenated at 100° C.
  2. filtrationThe catalyst is filtered off with suction
  3. concentrationthe filtrate is concentrated
  4. distillationthe residue is distilled

Sources & evidence

ORD record
ord-b96b4ffeffe243fcbe27e5972620a7df
Source dataset
uspto-grants-1993_01
Patent number
US05177210

Reaction notes

Loading…