HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1646069Generated: November 1, 2026
Water → 3-Benzyl-5-cyano-2-ethyl-7-methylimidazo[4,5-b]pyridine
https://huagongshe.com/reaction/1646069
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 3-Benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine | HCID 19385661 | — |
| Reactant | HCID 178418546 | HCID 178418546 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 3-Benzyl-5-cyano-2-ethyl-7-methylimidazo[4,5-b]pyridine | HCID 19385616 | 93.9% |
Reaction Steps
A mixture of 620 mg (1.8 mmol) of the product of Step D and CuCN (806 mg, 9.0 mmol) was heated in pyridine (4 mL) at reflux for 10 hours under nitrogen. The reaction was cooled, then water (50 mL), KCN (1.17 g), and EtOAc (20 mL) were added and the mixture was heated to 50° C. for 5 min. Cooling and extraction with EtOAc (2×50 mL) gave 467 mg of the title compound as a tan solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05177074 |
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| Source dataset | uspto-grants-1993_01 |
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| ORD ID | ord-194631e049b344bcbc2db254c6505679 |
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| Source note | uspto-grants-1993_01 |
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