反应详情

温度

50 °C

A mixture of 620 mg (1.8 mmol) of the product of Step D and CuCN (806 mg, 9.0 mmol) was heated in pyridine (4 mL) at reflux for 10 hours under nitrogen. The reaction was cooled, then water (50 mL), KCN (1.17 g), and EtOAc (20 mL) were added and the mixture was heated to 50° C. for 5 min. Cooling and extraction with EtOAc (2×50 mL) gave 467 mg of the title compound as a tan solid.

1. temperatureat reflux for 10 hours under nitrogen
2. temperatureThe reaction was cooled
3. temperatureCooling
4. extractionextraction with EtOAc (2×50 mL)