HuagongsheHuagongshe Chemistry Print Report · For research reference only
4,4'-Dihydroxybiphenyl → 1,1'-Biphenyl, 4,4'-dimethoxy-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4,4'-Dihydroxybiphenyl | HCID 7112 | — |
| Reactant | 4-Bromoanisole | HCID 7730 | — |
| Reactant | 4-Bromophenol | HCID 7808 | — |
| Product | 2-Bromobenzoic acid | HCID 6940 | — |
| Product | 1,1'-Biphenyl, 4,4'-dimethoxy- | HCID 16484 | 35% |
Reaction Steps
However, Busch et al. found that with aromatic compounds containing polar substituents, the selectivity to biphenyls was much lower. For example, p-bromophenol gave ca. 13.4% 4,4'-dihydroxybiphenyl, p-bromoanisole gave ca. 35% 4,4'-dimethoxybiphenyl, bromobenzoic acid gave 40% 4,4'-biphenyldicarboxylic acid and 3-bromobenzoic acid gave 56.5% 3,3'-biphenyldicarboxylic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05177258 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-6c322c571a7648399c8d3497427d5a68 |
| Source note | uspto-grants-1993_01 |