Sodium Methoxide → HCID 23678949, compound

HRID 1646142Notes

Reaction equation

HRID 1646142 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([O:9][CH3:10])[N:6]=[C:5]([O:11][CH:12]([C:16]([O:19][CH2:20][CH3:21])([CH3:18])[CH3:17])[C:13]([OH:15])=[O:14])[N:4]=1.C[O-].[Na+:24]>CO>[CH3:10][O:9][C:7]1[CH:8]=[C:3]([O:2][CH3:1])[N:4]=[C:5]([O:11][CH:12]([C:16]([O:19][CH2:20][CH3:21])([CH3:17])[CH3:18])[C:13]([O-:15])=[O:14])[N:6]=1.[Na+:24]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 157671522-[(4,6-Dimethoxypyrimidin-2-yl)oxy]-3-ethoxy-3-methylbutanoic acid

Product 1

HCID 23678949HCID 23678949, compoundYield 99.3%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To Compound 52 (30.0 g, 0.1 mol) prepared in the above (2) dissolved in methanol (100 ml) was added sodium methoxide (19.3 g, 28% methanol solution), and the mixture was stirred for 10 minutes. Subsequently, methanol was removed under reduced pressure to obtain 32 g of the title compound as white crystals.

Workup

  1. customSubsequently, methanol was removed under reduced pressure

Sources & evidence

ORD record
ord-0f35a6820bf24157b3cc4cc1e8caa4e4
Source dataset
uspto-grants-1993_01
Patent number
US05178663

Reaction notes

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