反应详情

1.8 g of dodecanoyl chloride and 2.0 ml of triethylamine are added to a solution of 1.65 g of 8-cyclohexadecen-1-ol in 25 ml of diethyl ether. After heating to reflux for 5 hours, the mixture is poured into 100 ml of H2O, the organic phase is separated off, the aqueous phase is extracted with 25 ml of diethyl ether, and the combined organic phases are evaporated in vacuo. Purification of the residue by chromatography on silica gel using dichloromethane/hexane 1:3 gives 1.05 g of 8-cyclohexadecen-1-yl dodecanoate as a viscous oil.

1. temperatureAfter heating
2. temperatureto reflux for 5 hours
3. customthe organic phase is separated off
4. extractionthe aqueous phase is extracted with 25 ml of diethyl ether
5. customthe combined organic phases are evaporated in vacuo
6. customPurification of the residue by chromatography on silica gel