HCID 53839528, compound → HCID 19801609, compound

HRID 1646176Notes

Reaction equation

HRID 1646176 reaction equation
[CH2:1]([O:3][P:4]([O:22][CH2:23][CH3:24])([CH2:6][CH:7]=[CH:8][C:9]1[CH:10]=[C:11]([NH:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:12]=[CH:13][CH:14]=1)=[O:5])[CH3:2]>C(O)C.[Pd]>[CH2:23]([O:22][P:4]([O:3][CH2:1][CH3:2])([CH2:6][CH2:7][CH2:8][C:9]1[CH:10]=[C:11]([NH:15][CH2:16][C:17]([O:19][CH2:20][CH3:21])=[O:18])[CH:12]=[CH:13][CH:14]=1)=[O:5])[CH3:24]

Participants

4

Reactant 1

HCID 53839528HCID 53839528, compound

Product 1

HCID 19801609HCID 19801609, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A solution of ethyl N-[3-[3-(diethoxyphosphinyl)1-propenyl]phenyl]glycinate (Example 2a) in ethanol (75 ml) is treated with 10% palladium on carbon (0.25 g) and shaken on a Parr apparatus under a hydrogen atmosphere (50 pounds per square inch (psi)). After filtration, the filtrate is evaporated and the residue purified over silica gel (ethyl acetate as eluant) to give 1.24 g of a clear oil.

Workup

  1. filtrationAfter filtration
  2. customthe filtrate is evaporated
  3. customthe residue purified over silica gel (ethyl acetate as eluant)

Sources & evidence

ORD record
ord-d49f58636c0a4eb1a22ba067f410c803
Source dataset
uspto-grants-1993_01
Patent number
US05179085

Reaction notes

Loading…