2-Methyloctahydropyrrolo(3,4-c)pyrrole → 4,9-Dihydro-3-methyl-4-[[7-methyl-3,7-diazabicyclo[3.3.0]oct-3-yl]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

HRID 1646190노트

반응식

HRID 1646190 반응식
Cl[C:2]([N:4]1[C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[NH:8][C:7](=[O:15])[C:6]2=[CH:16][S:17][C:18]([CH3:19])=[C:5]12)=[O:3].[CH3:20][N:21]1[CH2:28][CH:27]2[CH:23]([CH2:24][NH:25][CH2:26]2)[CH2:22]1>C(O)C>[CH3:19][C:18]1[S:17][CH:16]=[C:6]2[C:7](=[O:15])[NH:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:4]([C:2]([N:25]3[CH2:26][CH:27]4[CH:23]([CH2:22][N:21]([CH3:20])[CH2:28]4)[CH2:24]3)=[O:3])[C:5]=12

참가 물질

4

반응물 2

HCID 129585332-Methyloctahydropyrrolo(3,4-c)pyrroleHCID 142099804-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one

생성물 1

HCID 198016774,9-Dihydro-3-methyl-4-[[7-methyl-3,7-diazabicyclo[3.3.0]oct-3-yl]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one수율 13%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 3-methyl-3,7-diazabicyclo-[3.3.0]octane in a yield of 13% of theory. Colourless crystals of m.p. 220°-222° C. (ethanol).

출처 및 근거

ORD 기록
ord-2ec2108d8ede48b68da3bbf2609cfe18
출처 데이터셋
uspto-grants-1993_01
특허 번호
US05179090

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