HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyloctahydropyrrolo(3,4-c)pyrrole → 4,9-Dihydro-3-methyl-4-[[7-methyl-3,7-diazabicyclo[3.3.0]oct-3-yl]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyloctahydropyrrolo(3,4-c)pyrrole | HCID 12958533 | — |
| Reactant | 4-chlorocarbonyl-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 14209980 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4,9-Dihydro-3-methyl-4-[[7-methyl-3,7-diazabicyclo[3.3.0]oct-3-yl]carbonyl]-10H-thieno[3,4-b][1,5]benzodiazepin-10-one | HCID 19801677 | 13% |
Reaction Steps
Prepared analogously to Example 1 from 4-(chlorocarbonyl)-4,9-dihydro-3-methyl-10H-thieno[3,4-b][1,5]benzodiazepin-10-one and 3-methyl-3,7-diazabicyclo-[3.3.0]octane in a yield of 13% of theory. Colourless crystals of m.p. 220°-222° C. (ethanol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05179090 |
| Source dataset | uspto-grants-1993_01 |
| ORD ID | ord-2ec2108d8ede48b68da3bbf2609cfe18 |
| Source note | uspto-grants-1993_01 |