2-Chloro-N,N-dimethylethylamine → 11-Amino-4,5-dihydro-2-(2-dimethylaminoethyl)-2H-pyrazolo [3,4-a]acridine

Participants

Reaction Steps

To a solution of 11-amino-4,5-dihydro-1H-pyrazolo[3,4-a]acridine (8.0 g) in dry DMF (240 ml) was slowly added NaH (60%)(1.69 g). The reaction was stirred at room temperature for one hour, 2-dimethylaminoethylchloride (4.64 g) was added and stirring was continued for two hours. An additional 4.64 g of 2-dimethylaminoethylchloride was added and the reaction was stirred at room temperature overnight.

Provenance & Evidence