Hydrochloric Acid → Propanamide, N-(2,3-dihydro-1H-inden-2-yl)-

HRID 1646224Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1646224
ClCCl.Cl.[NH2:5][CH:6]1[CH2:14][C:13]2[C:8](=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH2:7]1.[C:15](Cl)(=[O:18])[CH2:16][CH3:17].Cl>C(N(CC)CC)C>[CH2:7]1[C:8]2[C:13](=[CH:12][CH:11]=[CH:10][CH:9]=2)[CH2:14][CH:6]1[NH:5][C:15](=[O:18])[CH2:16][CH3:17]

Komponenten

6

Edukt 4

HCID 313Hydrochloric AcidHCID 6344DichloromethaneHCID 62324Propionyl chlorideHCID 1227642-Aminoindan hydrochloride

Produkt 1

HCID 11701165Propanamide, N-(2,3-dihydro-1H-inden-2-yl)-Ausbeute 87,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8471TriethylamineLösungsmittel

Versuchsvorschrift

200 ml of dichloromethane, then 15 ml, i.e. 10.9 g (107.6 mmmol) of triethylamine were added to 5 g (29.5 mmol) of 2-aminoindan hydrochloride. The mixture was stirred, then 2.6 ml (29.5 mmol) of propionyl chloride were added and stirring was continued at room temperature for 12 h. Dilute hydrochloric acid was added, the precipitate was filtered, washed, dried and purified by chromatography on a silica gel column, eluted with an 80:20 mixture of dichloromethane/ethyl acetate. 4.87 g of beige solid were isolated.

Aufarbeitung

  1. stirringstirring
  2. filtrationthe precipitate was filtered
  3. washwashed
  4. customdried
  5. custompurified by chromatography on a silica gel column
  6. washeluted with an 80:20 mixture of dichloromethane/ethyl acetate

Quellen und Nachweise

ORD-Eintrag
ord-4a1ba56516eb4044906c6cffa3ac1196
Quelldatensatz
uspto-grants-1993_01
Patentnummer
US05179108

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