Hydrochloric Acid → HCID 19392432, compound

18.6 g of ethyl 4-chloro-4,4-difluorobutyrate are stirred with 100 ml of 2N-NaOH at room temperature until a homogeneous solution has been produced. The solution is then poured into 150 ml of 2N-HCl. The organic phase which has separated out is taken up in diethyl ether, dried with sodium sulfate and, after removal of the ether by distillation, distilled in vacuo. 12.6 g of 4-chloro-4,4-difluorobutyric acid are obtained in the form of a colourless oil of boiling point 88°-90° C./11 mbar.

1. customhas been produced
2. customThe organic phase which has separated out
3. dry with materialdried with sodium sulfate
4. customafter removal of the ether
5. distillationby distillation
6. distillationdistilled in vacuo

ORD record

ord-b63dc230d33948ada20059a225b173c8

Source dataset

uspto-grants-1993_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05179121