Thionyl Chloride → HCID 19801962, compound

HRID 1646269Notes

Reaction equation

HRID 1646269 reaction equation
[Cl:1][C:2]([F:9])([F:8])[CH2:3][CH2:4][C:5](O)=[O:6].S(Cl)([Cl:12])=O>CN(C)C=O>[Cl:1][C:2]([F:9])([F:8])[CH2:3][CH2:4][C:5]([Cl:12])=[O:6]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 19392432HCID 19392432, compound

Product 1

HCID 19801962HCID 19801962, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

15.8 g of 4-chloro-4,4-difluorobutyric acid are mixed with 50 ml of thionyl chloride and 0.2 ml of dimethylformamide and heated to +70° C. over the course of 2 hours and then maintained at +70° C. for a further 30 minutes. The reaction mixture is distilled in vacuo, and the liquid boiling at 35°-37° C./21 mbar is collected. 10.5 g of 4-chloro-4,4-difluorobutyryl chloride are obtained in the form of a clear colourless liquid.

Workup

  1. temperatureheated to +70° C. over the course of 2 hours
  2. temperaturemaintained at +70° C. for a further 30 minutes
  3. distillationThe reaction mixture is distilled in vacuo
  4. customthe liquid boiling at 35°-37° C./21 mbar is collected

Sources & evidence

ORD record
ord-e87df4414855489f94ee128a0dd249d4
Source dataset
uspto-grants-1993_01
Patent number
US05179121

Reaction notes

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