Hydrochloric Acid → HCID 15670187, compound

HRID 1646286Notes

Reaction equation

HRID 1646286 reaction equation
[Na+].[C:2]([S:5][CH2:6][CH:7]([CH2:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:8]([NH:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([O-:16])=[O:15])=[O:9])(=[O:4])[CH3:3].Cl>O>[C:2]([S:5][CH2:6][CH:7]([CH2:20][CH2:21][CH2:22][C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:8]([NH:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([OH:16])=[O:15])=[O:9])(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23701008HCID 23701008, compound

Product 1

HCID 15670187HCID 15670187, compoundYield 77.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-[(2-Acetylthiomethyl-5-phenylpentanoyl)amino]benzoic acid sodium salt (compound of Example 38) (1.5 g) is dissolved in water (30 ml), and the mixture is adjusted to pH 2.5 with 10% hydrochloric acid under ice cooling, and the mixture is extracted with ethyl acetate (50 ml). The extract is washed with water and dried over anhydrous magnesium sulfate, and then ethyl acetate is distilled off to give the title compound (1.1 g).

Workup

  1. extractionthe mixture is extracted with ethyl acetate (50 ml)
  2. washThe extract is washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationethyl acetate is distilled off

Sources & evidence

ORD record
ord-4da96a28bad242bb92f2f01dbb1b7928
Source dataset
uspto-grants-1993_01
Patent number
US05179125

Reaction notes

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