Hydrochloric Acid → HCID 15670189, compound

HRID 1646287Notes

Reaction equation

HRID 1646287 reaction equation
[Na+].[C:2]([S:5][CH2:6][CH:7]([CH2:20][C:21]1[CH:26]=[CH:25][C:24]([F:27])=[CH:23][CH:22]=1)[C:8]([NH:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([O-:16])=[O:15])=[O:9])(=[O:4])[CH3:3].Cl>O>[C:2]([S:5][CH2:6][CH:7]([CH2:20][C:21]1[CH:22]=[CH:23][C:24]([F:27])=[CH:25][CH:26]=1)[C:8]([NH:10][C:11]1[CH:12]=[C:13]([CH:17]=[CH:18][CH:19]=1)[C:14]([OH:16])=[O:15])=[O:9])(=[O:4])[CH3:3]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23701009HCID 23701009, compound

Product 1

HCID 15670189HCID 15670189, compoundYield 84.7%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

3-[[2-Acetylthiomethyl-3-(4-fluorophenyl)propionyl]amino]benzoic acid sodium salt (compound of Example 40) (0.5 g) is dissolved in water (10 ml), and the mixture is adjusted to pH 2.5 with 1N hydrochloric acid with stirring under ice cooling, and the mixture is extracted with ethyl acetate (20 ml). The extract is washed with water and dried over anhydrous magnesium sulfate, and then ethyl acetate is distilled off to give the title compound (0.4 g).

Workup

  1. extractionthe mixture is extracted with ethyl acetate (20 ml)
  2. washThe extract is washed with water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. distillationethyl acetate is distilled off

Sources & evidence

ORD record
ord-16c985e8f1394dcb91b75866e5267d06
Source dataset
uspto-grants-1993_01
Patent number
US05179125

Reaction notes

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