Hydrochloric Acid → HCID 86746487, compound

HRID 1646292Notes

Reaction equation

HRID 1646292 reaction equation
[SH:1][CH2:2][CH:3]([CH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11])=[O:5].[ClH:23]>C(O)C>[ClH:23].[SH:1][CH2:2][CH:3]([CH2:16][C:17]1[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=1)[C:4]([NH:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][CH:15]=1)[C:10]([OH:12])=[O:11])=[O:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 15670202HCID 15670202, compound

Product 1

HCID 86746487HCID 86746487, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3-[[2-Mercaptomethyl-3-(3-pyridyl)propionyl]amino]benzoic acid (compound of Example 54) (0.2 g) is dissolved in ethanol (20 ml), and thereto is added 35% ethanolic hydrochloric acid (0.3 ml), and the mixture is stirred at room temperature for 5 minutes, and ethanol is distilled off under reduced pressure. To the residue is added diethyl ether (30 ml), and the mixture is cooled. The precipitated white powder is taken by filtration to give the title compound (0.15 g).

Workup

  1. distillationethanol is distilled off under reduced pressure
  2. additionTo the residue is added diethyl ether (30 ml)
  3. temperaturethe mixture is cooled
  4. filtrationThe precipitated white powder is taken by filtration

Sources & evidence

ORD record
ord-e04f98a8ac304394a96b6ad944034cfc
Source dataset
uspto-grants-1993_01
Patent number
US05179125

Reaction notes

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