反应详情

To a solution dissolved 21.3 g (0.1 mol) of (6-methoxy-2-naphthyl)acetic acid in tetrahydrofuran anhydride (200 ml) was slowly added 19.0 g (0.15 mol) of oxalyl chloride and 1 ml of dimethylformamic at 0° C. After stirring at the room temperature for 15 hours, solvent and an excess of oxalyl chloride were removed to nearly quantitatively yield (6-methoxy-2-naphthyl)-acetyl chloride as product.

1. customdimethylformamic at 0° C
2. customsolvent and an excess of oxalyl chloride were removed to nearly quantitatively yield (6-methoxy-2-naphthyl)-acetyl chloride as product