反应详情

A solution of 4.9 g of sodium cyanide in 10 ml of water and a solution of 7.2 g of isobutyraldehyde in 30 ml of methanol are added dropwise with ice-cooling to a mixture of 6.4 g of 1-amino-2,6-dimethylpiperidine, 60 ml of water and 8.6 ml of concentrated hydrochloric acid. After stirring at room temperature for 8 days, the methanol is stripped off on a rotary evaporator and the solution is extracted with dichloromethane. The combined organic phases are washed with water of pH 5 containing acetic acid, dried and concentrated. 11.2 g of 2-((2,6-dimethylpiperidino)amino)-3-methylbutyronitrile remain, which are employed in the following step without further purification.

1. customthe methanol is stripped off on a rotary evaporator
2. extractionthe solution is extracted with dichloromethane
3. washThe combined organic phases are washed with water of pH 5
4. additioncontaining acetic acid
5. customdried
6. concentrationconcentrated
7. customwhich are employed in the following step without further purification