Dichloromethane → tert-Butyl 4-bromopiperidine-1-carboxylate

HRID 164642Notes

Reaction equation

HRID 164642 reaction equation
[C:15]([Br:16])([Br:17])([Br:18])[Br:19].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([OH:14])[CH2:12][CH2:13]1.[Cl:39][CH2:40][Cl:41].[c:20]1([P:21]([c:22]2[cH:23][cH:24][cH:25][cH:26][cH:27]2)[c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)[cH:34][cH:35][cH:36][cH:37][cH:38]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][CH:11]([Br:16])[CH2:12][CH2:13]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 11205Carbon tetrabromideHCID 11776TriphenylphosphineHCID 643502Tert-butyl 4-hydroxypiperidine-1-carboxylate

Product 1

HCID 15541517tert-Butyl 4-bromopiperidine-1-carboxylate

Sources & evidence

ORD record
ord-55d6d0ce00424f92b2a573b7caa9d44d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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