反应详情

A mixture of 12.5 g of 2-(5-amino-2-chloro-4-fluorophenylthio)-4-chlorobutyric acid ethyl ester, 10.6 g of potassium carbonate and 0.7 g of tetrabutylammonium hydrogen sulfate in 14 ml of toluene is maintained at +80° C. for 40 hours. The solid portions of the reaction mixture are then filtered off and washed with acetone. Evaporation of the solvent and recrystallisation from n-hexane and a small amount of ethyl acetate yield 7.9 g of 1-(5-amino-2-chloro-4-fluoro-phenylthio)-cyclopropanecarboxylic acid ethyl ester having a melting point of from +96° to +97° C.

1. temperatureis maintained at +80° C. for 40 hours
2. filtrationThe solid portions of the reaction mixture are then filtered off
3. washwashed with acetone
4. customEvaporation of the solvent and recrystallisation from n-hexane
5. customof from +96° to +97° C.