反应详情

A mixture of 12.5 g of 2-(5-amino-2-chloro-4-fluorophenylthio)-4-bromobutyric acid methyl ester, 30.4 g of potassium carbonate and 1.7 g of tetrabutylammonium hydrogen sulfate in 38 ml of toluene is maintained at +80° C. for 40 hours. The solid portions of the reaction mixture are then filtered off and washed with acetone. Evaporation of the solvent yields 17 g of 1-(5-amino-2-chloro-4-fluorophenylthio)-cyclopropanecarboxylic acid methyl ester having a melting point of from +119° to +124° C.

1. temperatureis maintained at +80° C. for 40 hours
2. filtrationThe solid portions of the reaction mixture are then filtered off
3. washwashed with acetone
4. customEvaporation of the solvent