反应详情

Triethylamine (1.1 g, 0.011 mol) is added dropwise to a mixture of 2-(trifluoromethyl)-4-(4-chlorophenyl)-3-oxazolin-5-one and α-bromo-p-chlorocinnamonitrile in 25 mL of acetonitrile and the mixture is stirred at room temperature for 18 hours. The reaction mixture is poured into 100 mL of water and extracted with two 30 mL portions of ethyl acetate. The combined extracts are washed with 30 mL of water, 30 mL of saturated brine, dried over magnesium sulfate, filtered and the solvent evaporated to leave a brown solid.

1. extractionextracted with two 30 mL portions of ethyl acetate
2. washThe combined extracts are washed with 30 mL of water, 30 mL of saturated brine
3. dry with materialdried over magnesium sulfate
4. filtrationfiltered
5. customthe solvent evaporated
6. customto leave a brown solid