Bromine → HCID 19746782, compound

HRID 1646499Notes

Reaction equation

HRID 1646499 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:20]#[N:21])=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[CH:12]=2)=[CH:4][CH:3]=1.[Br:22]Br.C([O-])(=O)C.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10]([C:20]#[N:21])=[C:11]([C:13]3[CH:18]=[CH:17][C:16]([Cl:19])=[CH:15][CH:14]=3)[C:12]=2[Br:22])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 24408BromineHCID 517045Sodium AcetateHCID 19746749HCID 19746749, compound

Product 1

HCID 19746782HCID 19746782, compoundYield 44%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromination of 2,4-bis(p-chlorophenyl)-5-cyanopyrrole is accomplished by treatment with 1 equivalent of bromine in acetic acid in the presence of anhydrous sodium acetate yields the desired product (0.47 g, yellow solid, 44% yield, mp 98°-100° C.

Sources & evidence

ORD record
ord-d3cf31a90c7d484195e9a1dc2e3c1840
Source dataset
uspto-grants-1993_01
Patent number
US05180734

Reaction notes

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