Trifluoroacetic acid → HCID 18649578, compound

HRID 1646534Notes

Reaction equation

C(OC([NH:8][C@@H:9]([CH2:17][CH:18]([CH3:20])[CH3:19])[CH2:10][N:11]1[CH2:16][CH2:15][O:14][CH2:13][CH2:12]1)=O)(C)(C)C.[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24]>>[F:21][C:22]([F:27])([F:26])[C:23]([OH:25])=[O:24].[O:14]1[CH2:15][CH2:16][N:11]([CH2:10][C@@H:9]([NH2:8])[CH2:17][CH:18]([CH3:19])[CH3:20])[CH2:12][CH2:13]1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 10989798HCID 10989798, compound

Product 1

HCID 18649578HCID 18649578, compound

Procedure

Crude N-tert-butoxycarbonyl-1-morpholino-2-(S)-amino-4-methylpentane (6.3 mmol) was dissolved in DCm (50 ml) and treated with excess trifluoroacetic acid (0.48 ml) at 0° C. The mixture was allowed to warm up to room temperature and was stirred for 3 h. The mixture was concentrated to dryness to give 1-morpholino-2-(S)-amino-4-methylpentane trifluoroacetate salt which was used immediately.

Workup

concentrationThe mixture was concentrated to dryness

Sources & evidence

ORD record: ord-546ac3d7259f4e9886b9fab6552345c6
Source dataset: uspto-grants-1993_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05180723

Reaction notes

Loading…