Water → HCID 19801183, compound

HRID 1646617Notes

Reaction equation

HRID 1646617 reaction equation
[Br:1][C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[CH2:4][CH2:5][CH:6]2[OH:11].[C:12](OC(=O)C)(=[O:14])[CH3:13].O.C(OC(C)C)(C)C>N1C=CC=CC=1>[C:12]([O:11][CH:6]1[C:7]2[C:3](=[C:2]([Br:1])[CH:10]=[CH:9][CH:8]=2)[CH2:4][CH2:5]1)(=[O:14])[CH3:13]

Participants

6

Reactant 4

HCID 962WaterHCID 7914Diisopropyl EtherHCID 7918Acetic AnhydrideHCID 133302084-Bromo-1-indanol

Product 1

HCID 19801183HCID 19801183, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

3.0 g of 4-bromo-1-indanol (RS) in 30 ml of pyridine is cooled to 0° C., 2 ml of acetic anhydride is introduced slowly with agitation for 17 hours at ambient temperature. It is then poured into 100 ml of water and 100 ml of isopropyl ether and decanted; the organic phase is washed with water, dried and concentrated to dryness. The residue is taken up in 1,2-dichloro ethane in order to eliminate the pyridine by azeotropy. 3.9 g of expected product is obtained.

Workup

  1. customdecanted
  2. washthe organic phase is washed with water
  3. customdried
  4. concentrationconcentrated to dryness

Sources & evidence

ORD record
ord-4de8e6bed6bc42639204524469fc9528
Source dataset
uspto-grants-1993_01
Patent number
US05180741

Reaction notes

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