Acetic Anhydride → HCID 136058307, compound

HRID 1646676Notes

Reaction equation

HRID 1646676 reaction equation
[CH3:1][S:2][C:3](=[NH:8])[NH:4][N+:5]([O-:7])=[O:6].[C:9](OC(=O)C)(=[O:11])[CH3:10]>N1C=CC=CC=1>[C:9]([NH:8][C:3](=[N:4][N+:5]([O-:7])=[O:6])[S:2][CH3:1])(=[O:11])[CH3:10]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 135927615N-Nitro-S-methylisothiourea

Product 1

HCID 136058307HCID 136058307, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

To a mixture of 5.0 g of S-methyl-N-nitroisothiourea and 25 ml of pyridine was dropwise added 11.3 of acetic anhydride at room temperature over 10 min. After completion of the addition the mixture was stirred at room temperature for 5 hours, and the reaction mixture concentrated. The residue was poured onto 50 ml of 2N hydrochloric acid, and crystals then formed collected by filtration and dried. There was obtained 5.1 g of N-acetyl-S-methyl-N'-nitroisothiourea as white crystals, mp 109°-110° C.

Workup

  1. additionAfter completion of the addition the mixture
  2. concentrationthe reaction mixture concentrated
  3. additionThe residue was poured onto 50 ml of 2N hydrochloric acid, and crystals
  4. customthen formed
  5. filtrationcollected by filtration
  6. customdried

Sources & evidence

ORD record
ord-2a4755a8dd6a41318fc64cd9e5c8b243
Source dataset
uspto-grants-1993_01
Patent number
US05180833

Reaction notes

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